PEP19™

The world's first naturally occurring peptide to restore metabolic health (RMH™).

When it comes to metabolic-restoration support peptide therapeutics, PEP19 safely supports metabolism and helps restore natural function
About

PEP19™

A Novel Approach to Metabolic Health

.It remodels body composition, upports the reduction of visceral fat and helps improve metabolic function, regardless of weight and without adverse side effects – a favorable safety profile in all studies.

PEP19 is a naturally occurring bioactive peptide positioned to restore metabolic health. For the 41.5% of adults globally struggling with central obesity, weight management and nearly half of the adult population facing early metabolic risks, this first-of-its-kind metabolic peptide is set to change the landscape.

This capsule offers a safe, side-effect-free, alternative metabolic support approach for individuals battling weight managment and obesity, type- 2 diabetes, and insulin resistance. It is especially promising for populations who require alternative options for metabolic control, such as those intolerant to current GLP-1 treatments, postmenopausal women, and those managing chronic hypertension and even sleep disorders. By addressing key pathways related to the root causes of cardiometabolic health impact, PEP19 remodels high-risk body fat with a favorable safety profile in studies, without causing lean muscle loss, brain effects, or gastrointestinal distress.

PEP19 Explained

Taken as a simple 10 mg daily oral capsule, PEP19 works from within to support metabolic function. Unlike treatments that rely solely on appetite suppression, PEP19 employs a unified mechanism: it promotes a “browning-like” effect in white fat tissue while simultaneously enhancing the body’s insulin efficiency. This active remodeling of fat tissue safely restores healthy metabolism without requiring drastic behavioral changes or causing adverse symptoms.

The Novel Science Behind

At the cellular level, PEP19 fundamentally addresses metabolic signaling by modulating the peripheral CB1 cannabinoid receptor (CB1R). This highly controlled approach triggers UCP1 activation and thermogenesis, effectively supports the conversion of stored white fat into heat. The result is a precise redistribution of the body’s fat – specifically targeting and reducing dangerous visceral fat around the organs – while significantly improving insulin resistance and cardiovascular markers, all completely independent of weight loss.

Proven Human Efficacy and FDA Approved Safety

The efficacy of PEP19 is supported by independent clinical validation, a Self-Affirmed GRAS (Generally Recognized as Safe), and a growing pipeline of global patents extending through 2033.

PEP19, also known as WATACAP, has undergone a rigorous regulatory process to achieve Self-Affirmed Generally Recognized As Safe (GRAS) status. The process was led by Corey Hilmas, MD, PhD, Chief Regulatory Officer of KGK Science Inc. >>read 

Human Clinical Trials Outcomes:

  • 6% reduction in HbA1c metabolic markers and improved insulin sensitivity
  • 17% reduction in visceral fat
  • 8% reduction in android-to-gynoid fat ratio (DEXA)
  • 14% reduction in abdominal skinfold thickness

Proven Safety Profile

Multiple human clinical trials, spanning 60 to 90 days, have consistently reported a favorable safety profile showing no adverse effects. Findings include the preservation of lean muscle mass and an absence of gastrointestinal distress, further establishing PEP19 as a safe option for consumption.

  • Neurological Safety – designed to act peripherally (does not cross the blood-brain barrier)
  • No behavioral changes required
  • Efficacy is not dependent on weight
  • No lean mass loss
  • No provocation of anxious or depressive behaviors.
  • Non toxic – no safety concerns observed in studies
  • Non allergenic – no safety concerns observed in studies

Clinically Validated Benefits

PEP19™ delivers measurable metabolic improvements through a targeted peripheral mechanism
Key Mechanics
Reduces Visceral Fat

Targets adipose tissue directly for measurable fat reduction
Key Mechanics
Improves Insulin Sensitivity
Targets adipose tissue directly for measurable fat reduction
Key Mechanics
Preserves Lean Mass

Maintains muscle tissue while reducing fat
Key Mechanics
Peripheral Mechanism

No CNS effects or behavioral modifications required

Product Applications

Regulatory Approvals and Acknowledged Claims
Weight Management & Body Composition
  • Supports reduction of visceral fat, body weight, and waist circumference in generally healthy but overweight adults.
  • Supports a healthy body composition and fat loss in generally healthy but overweight adults.
  • Serves as a healthy weight reduction strategy for generally healthy but overweight adults.
  • Supports healthy weight management.
Scales, measuring tape and oranges on wooden background, closeup. Weight loss

Scientific Publications

Pep19: A Novel Approach for Reducing Visceral Fat and Improving Sleep Quality in Obese Adults—Results From an Early-Stage Clinical Trial
Journal: Diabetes/Metabolism Research and Reviews (Wiley)
Year: 2025
Safety of white adipose tissue activator cyclophilin A intracellular peptide (Pep19™) in healthy dogs
Journal: The Veterinary Journal (Elsevier)
Year: 2024
Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
Journal: International Journal of Molecular Sciences (MDPI)
Year: 2022
A novel peptide that improves metabolic parameters without adverse central nervous system effects
Journal: Scientific Reports (Nature Publishing Group)
Year: 2017
Frequently Asked Questions

Scientific answers to common questions about us and our health platform

PEP19 is Proteimax’s lead metabolic health peptide, commercially launched in 2025 as a metabolic-restoration solution.
PEP19 RMH capsules are available through Heliox Health, the official distributor for the U.S. and Canadian markets.
PEP19 has completed four human clinical trials, including two open-label and two placebo-controlled ones. The positive results have been widely published in scientific journals.
PEP19 is a 10-amino-acid peptide that targets visceral fat and hyperglycemia by modulation of the peripheral CB1 receptor in white adipose tissue. It is formulated as a 10 mg oral capsule.
Clinical trials showed a 17% reduction in visceral fat and a 6% reduction in HbA1c, with no adverse effects or loss of lean mass
Global Distribution Partners
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HelioXHealth
For PEP19 RMH capsules in the USA Please contact Heliox Health
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Join us to revolutionize the use of bioactive peptides to  better lives worldwide. Our biotechnology advances peptide therapeutics through focused discovery, grounded in deep peptide expertise.

Our partners across pharma, food, biology, and beyond help drive the global market impact of novel peptide therapeutics.

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Headquarters

Proteimax Israel (HQ)
Proteimax Americas (US Office)
Proteimax Brazil (R&D Center)

Email

info@proteimax.com

This contact channel is reserved for potential corporate partnerships only. If you are a consumer with questions about PEP19, please reach out to your local territory distributor.

For USA inquiries, please contact